Dusting Powder Presentation

ITRACONAZOLE 1% W/W 75 g

It belongs to the triazole class of antifungal drugs. It is used to treat fungal infections in immunocompromised and non-immunosuppressed patients. It inhibits endogenous respiration and prevents transformation of yeast mycelial forms. It inhibits the triglyceride and phospholipid biosynthesis.

Indications

• Histoplasmosis
• Blastomycosis
• Cryptococcal meningitis
• Aspergillosis
• Onychomycosis
• Vulvovaginal candidiasis

Mechanism of Action

Itraconazole inhibits the enzyme 14-alpha demethylase which is cytochrome P-450-dependent enzymes which is responsible for conversion of lanosterol to ergosterol which is the component of fungal cell membrane.

Pharmacokinetics

Absorption- It is orally absorbed
Protein Binding- It shows 99% protein binding
Metabolism- It is metabolized by N-dealkylation in the liver
Excretion- It is excreted via urine

Side Effects

• Bloating
• Blistering
• Blood in urine
• Itching
• Numbness
• Burning
• Black stools

Drug Interactions

• Rifampicin
• Phenytoin
• Carbamazepine
• Phenobarbital

Contraindication

• Contraindicated in chronic heart failure
• Contraindicated in kidney disorders
• Contraindicated in heart valve disease